Angels vs Orioles MLB Opening Day Prediction, Odds & Best Bets (3/28): Santander Steps Up

This Angels vs Orioles MLB prediction and Opening Day best bets are brought to you by Bovada. Bovada is a market leader in sports betting, offering various options from the MLB to the NBA and everything in between.

After months of waiting, Opening Day for the 2024 MLB season is finally here. There are several highly anticipated matchups scheduled for baseball’s return, including a clash between the Los Angeles Angels (0-0) and Baltimore Orioles (0-0) at 3:05 p.m. ET.

BASEBALL IS BACK! ⚾️⚾️⚾️#OpeningDay pic.twitter.com/GbGrhecHCA

— MLB Network (@MLBNetwork) March 28, 2024

The Angels begin life without Shohei Ohtani following a disappointing 2023 campaign that saw them go 73-89, missing the playoffs for the ninth consecutive season. Meanwhile, the Orioles are fresh off their first 100-win campaign in over 80 years and hope to start the season on a high note after getting swept by the Texas Rangers in the ALDS.

As the new schedule is set to begin, Baltimore currently owns the fifth-best 2024 World Series odds (+950) while Los Angeles sits 25th (+12000), per Bovada’s MLB futures markets.

This afternoon’s matchup is also filled with promising betting opportunities, which you can learn more about by reading through my Angels vs. Orioles prediction and best bets.

Angels vs Orioles MLB Opening Day Betting (3/28)

Angels vs Orioles Opening Day Information

• Matchup: Los Angeles Angels (0-0, 0-0 Away) vs. Baltimore Orioles (0-0, 0-0 Home)
• Venue & Location: Oriole Park at Camden Yards (Baltimore, MD)
• Date: Thursday, March 28, 2024
• Game Time: 3:05 p.m. ET
• How to Watch Angels vs. Orioles: MLB.TV, MASN, Bally Sports West

Angels vs Orioles Probable Pitchers

• Angels: Patrick Sandoval (0 starts — 0-0, 0.00 ERA)
• Orioles: Corbin Burnes (0 starts — 0-0, 0.00 ERA)

Orioles vs Angels Odds & Spread

Orioles vs. Angels Opening Day odds are courtesy of Bovada as of Thursday, March 28 at 9:04 a.m. ET. Odds from other top online sportsbooks may also be mentioned in this article.

Angels vs Orioles Run Line

• Los Angeles Angels +1.5 (-140)
• Baltimore Orioles -1.5 (+120)

Orioles vs Angels Over/Under

• Over 7.5 Runs (-115)
• Under 7.5 Runs (-105)

Angels vs Orioles Moneyline

• Los Angeles Angels (+143)
• Baltimore Orioles (-174)

You might also like: 3 Best MLB Long Shot Future Bets

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Angels vs Orioles MLB Betting Trends

• The Angels are 1-5 straight up in their last six games vs. Baltimore.
• Baltimore is 1-4 straight up in its last five games vs. the AL West.
• The total hit the Over in four of the Angels’ last five road games.
• The total hit the Under in seven of Baltimore’s last eight home games.
• The total hit the Over in seven of the last eight Angels-Orioles matchups.

Angels vs Orioles Opening Day Prediction & MLB Picks Today (3/28): O’s Step Up

As both teams prepare to begin the 2024 MLB season, the Angels hope to perform better against the Orioles than they did last year.

These clubs clashed seven times during the previous season, resulting in five victories for the Orioles. The Angels couldn’t figure out how to string together consecutive wins as they were outscored 41-29 across the season-long series. Having said that, Los Angeles did win two of the four games at Camden Yards.

Still, the Angels have an uphill battle ahead of them this season now that Shohei Ohtani joined the Dodgers. Yes, they still have the likes of Mike Trout and Anthony Rendon, but Ohtani is a two-time AL MVP winner and finished fourth in Cy Young voting just two years ago. It’s going to take a lot to replace the dual-threat phenom.

The Angels also had a fairly average offense last season, so it’s easy to imagine things worsening with Ohtani’s departure.

On the flip side, the young Orioles averaged the seventh-most runs in 2023 and could be even more dangerous with the extra experience under their belts.

Anthony Santander was tied for the team lead with 28 home runs during the 2023 season. 

When it comes to the Opening Day starting pitchers, the Angels are sending Patrick Sandoval to the mound. The veteran lefty is coming off a 2023 campaign that was quite mixed. After going 6-7 with a 3.95 ERA in his first 18 starts, the former 2015 11th-rounder pitched to a 1-6 record with a 4.44 ERA in his final 10 appearances.

Furthermore, Sandoval recorded a loss against the Angels on Sept. 6 after allowing four earned runs on seven hits over five innings of work.

Meanwhile, the Orioles are rolling with Corbin Burnes, who was acquired from the Milwaukee Brewers in February. Burnes, who won the NL Cy Young in 2021, is coming off a strong year that saw him go 10-8 with a 3.39 ERA and NL-leading 1.069 WHIP across 32 starts.

How will Corbin Burnes perform in his first-ever start as an Oriole this afternoon? 

The Angels were bad last season and will only be worse without Ohtani. In other words, take the Orioles to win. Baltimore was one of Major League Baseball’s best teams in 2023 and will only improve with each passing game. With the Camden Yards crowd on their side, this game is the O’s to lose.

With that in mind, I’m also taking the Orioles on the run line. The moneyline doesn’t hold much value, after all. Besides, the Orioles love facing left-handed pitchers, proven by their ranking 12th in home runs, sixth in RBIs, 10th in batting average, and seventh in on-base percentage against southpaws last season.

Considering how they had a 58.2% success rate (2nd) against the run line in 2023, I like the Orioles odds to cover again.

Angels vs Orioles MLB Prediction: BAL wins

Best Angels vs Orioles Bet: BAL -1.5 (+120)

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Best Angels vs Orioles Opening Day Prop Bet (3/28)

Although there are several Angels vs. Orioles player props worth targeting, I’m taking Anthony Santander to record over 1.5 total bases.

Santander was one of Baltimore’s most productive players last season. He recorded a career-high 279 total bases with 141 of those being tallied across 75 home games — an average of 1.9 per outing. Furthermore, the 29-year-old veteran outfielder has racked up 24 total bases in his last nine games against the Angels, finishing with two or more seven times.

After amassing six TBs in his last encounter with Sandoval, look for Santander to make an impact.