Guardians vs Yankees MLB Predictions, Odds & Best Bets (8/21)

Two of the American League’s top teams will meet on Tuesday when the Cleveland Guardians (73-52) and New York Yankees (73-53) collide in the Bronx. If you’re looking to get in on today’s Guardians vs. Yankees betting action, you’ve come to the right place.

Let’s stop wasting time, and get into my predictions and top MLB betting picks for tonight’s showdown.

2024 MLB Betting Picks Record: 76-90-1 (45.8%)

MLB Betting Today: Guardians vs Yankees (8/21)

Guardians vs Yankees Game Information

• Matchup: Cleveland Guardians (73-52, 35-32 Away) vs. New York Yankees (73-53, 32-28 Home)
• Venue & Location: Yankee Stadium (Bronx, NY)
• Date: Wednesday, Aug. 21, 2024
• Game Time: 7:05 p.m. ET
• How to Watch Guardians vs. Yankees: MLB.TV, Fubo, Prime Video

Guardians vs Yankees MLB Probable Pitchers

• Guardians: Joey Cantillo (3 starts — 0-2, 6.23 ERA)
• Yankees: Nestor Cortes (25 starts — 6-10, 4.20 ERA)

Yankees vs Guardians MLB Odds & Spread

Yankees vs. Guardians MLB odds are courtesy of BetOnline as of Wednesday, Aug. 21 at 11:15 a.m. ET. Odds from other top online sportsbooks may also be mentioned in this article.

Guardians vs Yankees Run Line

• Cleveland Guardians +1.5 (-128)
• New York Yankees -1.5 (+108)

Yankees vs Guardians Over/Under

• Over 8 Runs (-120)
• Under 8 Runs (+100)

Guardians vs Yankees Moneyline

• Cleveland Guardians (+169)
• New York Yankees (-185)

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Guardians vs Yankees MLB Betting Trends

• Cleveland is 6-14 straight up in its last 20 games as the underdog.
• The Yankees are 8-4 straight up in their last 12 games vs. Cleveland.
• The total hit the Under in four of Cleveland’s last six games.
• The total hit the Over in five of the Yankees’ last six home games.
• The total hit the Under in eight of the last 12 Guardians-Yankees matchups.

Guardians vs Yankees Predictions & MLB Picks Today (8/21)

The Guardians opened up this week’s series with a 9-5 win over the Yankees last night. The clubs needed three extra frames to decide a victor, leading to Cleveland scoring a whopping six runs in the 12th inning to notch its 73rd victory of the 2024 season.

The victory also marked the end of a three-game losing streak for the Guardians. Having said that, Cleveland is only 6-10 SU across its last 16 outings and has only won back-to-back road games once since August began, meaning it remains to be seen if the team’s latest victory was a fluke or not.

Meanwhile, the Yankees appear to be trending in the wrong direction. After an impressive 13-5 SU run from July 27 to Aug. 16, the Bronx Bombers have now lost three consecutive outings while being outscored 16-7 on aggregate, highlighting the need for improvement on both sides of the ball.

Wednesday is a lucky day of the week for New York, though. The Yankees are 13-5 SU across their last 18 ‘Hump Day’ matchups while the Guardians are just 2-5 SU in their last seven Wednesday contests.

Things haven’t gone well for the Guardians in their recent Wednesday matchups. 

Another statistic that’s in the Yankees’ favor is that they’re 8-4 SU across their last 12 meetings with the Guardians. In fact, New York has also beaten Cleveland in seven of their last 10 meetings at Yankee Stadium.

We’ll see if that trend continues as LHP Nestor Cortes draws the start for the Yankees. After a shaky month-long run, Cortes rebounded against the Chicago White Sox last week by striking out nine batters across seven scoreless innings in a 4-1 victory for New York. At the same time, it’s worth noting that he’s also allowed 12 earned runs on 17 hits in his last nine innings at Yankee Stadium.

Meanwhile, the Guardians are rolling with rookie LHP Joey Cantillo. The former 2017 16th-overall pick’s MLB career is off to a shaky starting with an 0-2 record and 6.23 ERA in his first three starts. He’s also surrendered four home runs in just 13 innings, which could come back to bite him against a Yankees team that averages the second-most HRs per game in the MLB.

Will veteran LHP Nestor Cortes lead the Yankees to victory? 

Tonight, we’re taking the Yankees to beat the Guardians. New York is hungry for revenge and a juicy opportunity is on the horizon based on Cantillo’s early struggles. Both teams are capable of winning, however, the Yankees clearly know how to beat the Guardians at home and I fully expect that trend to resume this evening.

With that in mind, I fully expect the 8-run total to be surpassed. For starters, the Over is an impressive 5-1 across New York’s last six home games (12.2 total runs per game). The Over is also 3-0 in the last three Guardians-Yankees matchups as the AL juggernauts averaged 13.0 total runs in those contests and just combined for 14 less than 24 hours ago.

Considering how both Cantillo and Cortes’ performances can be unpredictable, I won’t be shocked if we see fireworks in the Bronx tonight.

Guardians vs. Yankees MLB Prediction: NYY wins

Best Guardians vs. Yankees Bet: o8 Total Runs (-120)

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Best Guardians vs Yankees MLB Player Prop (8/21)

If we’re expecting a ton of runs tonight, it’s a no-brainer to back an anytime Aaron Judge home run (+150) as the best Guardians vs. Yankees player prop.

Judge heads into tonight’s showdown with an MLB-leading 45 home runs and his bat isn’t showing any signs of slowing down. The six-time MLB All-Star has racked up four HRs while batting .452 in his last eight games (31 at-bats) and just homered against Guardians last night. In fact, he’s now hit a round-tripper in back-to-back meetings with Cleveland.

If that isn’t convincing enough, Judge has amassed 12 HRs in 102 ABs against left-handed starters. Considering how Cantillo is surrendering a home run every four innings or so, you can see why this prop bet is extremely attractive.