FSU vs. Louisville Football Betting: ACC Rivals Set For High-Scoring Battle

The Florida State Seminoles and Louisville Cardinals will meet in Week 3 of the College Football season. The Seminoles enter the game 2-0, while the Cardinals sit at 1-1.

Louisville got a big road win last week at UCF. They had to rally in the second half, and their running game was a big part of the comeback.

Florida State held on for a road win at LSU last week, where the Tigers missed an extra point late in the game that would have tied it at 24. Instead, the Seminoles held on for a 24-23 victory.

Heading into the matchup on Friday night, both teams are looking for more structure in their early season play. Both teams have had to rally and hold on for wins within the first two weeks, so I expect a closer game to be played tonight.

FSU is a 3.5 point favorite heading into the game, but they are not the favorite to cover the spread. This proves that the game is expected to be close, and we should see it go down to the wire.

Florida State Seminoles vs. Louisville Cardinals Matchup Information & Betting Odds

Matchup Information

• Matchup: Florida State Seminoles (2-0) vs. Louisville Cardinals (1-1)
• Venue & Location: Cardinal Stadium (Louisville, Kentucky)
• Date: Friday, September 16, 2022
• Game Time: 7:30 p.m. Eastern Time
• How to Watch Florida State vs. Louisville: ESPN

Florida State vs. Louisville Odds

Game odds are via BetOnline. This article may also include odds from other legal online betting sites.

Spread

• Florida State -3.5 (+100)
• Louisville +3.5 (-122)

Over/Under

• Over 56.5 (-115)
• Under 56.5 (-105)

Moneyline

• Florida State -146
• Louisville +122

Florida State vs. Louisville History

Florida State and Louisville have met 22 times on the football field. The Seminoles hold the series edge 16-6, and it dates all the way back to 1952. In that first game, Louisville was victorious. However, they followed that win with 12 straight series losses.

The teams have been rivals in the ACC Conference since 2014. They have played every year since then, and they are tied 4-4 in wins since the Cardinals moved conferences.

The Cardinals are currently on a 2 game winning streak against the Noles, winning in 2020 and 2021. In 2020, Louisville played at home, and they blew out FSU by a score of 48-16.

The Cardinals have never won more than 2 in a row against the Seminoles, but they have a chance to extend the mark and win their 3rd straight tonight. They have played equally well at home and on the road, winning 3 games on each field.

In the last 5 games between the two, they have combined for no less than 52 points per contest. In 3 of those games, the point total went over the Over/Under mark of 56.5 for Friday.

With both teams seeking consistency, and a big win to open ACC play, expect another high-scoring battle. I see the totals for each team going into the 30s, as defense will be at a premium.

Florida State vs. Louisville Prediction and Betting Picks

Florida State vs. Louisville Prediction: Louisville 38, Florida State 35

Florida State vs. Louisville Picks: Over 57 total points (-110 at Bovada Sportsbook)

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