Sportsbook Promos
49ers vs. Rams | Week 3 Predictions & Best Bets
Written by: Varun Sharma
Last Updated:
Read Time: 5 minutes
nfl
San Francisco 49ers Odds
Spread
Total
Moneyline
-6.5
-105
44
-110o
-280
Los Angeles Rams Odds
Spread
Total
Moneyline
+6.5
-110
44
-105u
+240
Boost Your Winnings Now!
Claim 50% Match Up To $1,000
+ $10 Free Cash Bonus
(use promo code BNEWS)
Exclusive BetOnline Offer - Limited Time
See Picks & Statistics For The GameDivisional matchups are always just a little more exciting. The Rams and 49ers meet for the first time this year, coming to you live from SoFi Stadium in sunny Los Angeles.With so many injuries for both teams, we’ve got a lot to discuss; let’s jump right into it.
Here are our best bets for the 49ers vs Rams!
[su_icon icon="icon: star" class="font-weight-bold" background="#fff" color="#FB8500" text_color="#5C6571" size="16" shape_size="4" radius="256" text_size="12" url="/sportsbooks/betonline/" margin="0"] 5/5 Review Rating [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="" margin="0"] $10 Cash Bonus with code "BNEWS" [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="" margin="0"] Sports, Casino, Poker & Racebook [/su_icon]
49ers vs. Rams Game Information
SoFi Stadium; Los Angeles, California
Matchup Information
- Location: SoFi Stadium; Los Angeles, California
- Date: Sunday, September 22nd, 2024
- Kickoff: 4:25 PM EST
Quarterback Matchup
- San Francisco 49ers: Jacoby Brissett (1-1; 2024 – 135 YPG | 1 TD | 0 INT)
- Los Angeles Rams: Aaron Rodgers (1-1; 2024 – 171.5 | 3 TD | 1 INT)
Betting Odds
Odds via BetOnline, an industry leader in the sports betting world.
Run Line
- San Francisco 49ers -6 (-106)
- Los Angeles Rams +6 (-114)
Money Line
- San Francisco 49ers (-300)
- Los Angeles Rams (+250)
Total
- Over 43 (-115)
- Under 43 (-105)
Get 50% up to $1,000 on your NFL picks today at BetOnline
49ers vs. Rams Analysis & Breakdown
Fred Warner records the sack on Matthew Stafford.
We’re just two weeks deep into the NFL season and the injury bug has run amok. Both the Rams and the 49ers are missing multiple players on both sides of the ball, and both teams are missing big names on the offense.
The Rams lost Puka Nacua in Week 1 and saw their other star wideout, Cooper Kup, go down in Week 2.
The 49ers have been without their starting running back, Christian McCaffrey all season due to an inflamed hamstring, and now will be without Deebo Samuel for a few weeks due a calf injury.
It was just announced today that starting tight end for the 49ers, George Kittle, sat out practice on Thursday with a hamstring issue; his status for Sunday is now up in the air.
With such a big void left on both rosters, it’ll be interesting to see who steps up to fill in.
Brandon Aiyuk o72.5 Receiving Yards (-111) via BetOnline – Get a $500 WELCOME BONUS
Brandon Aiyuk hurdles a tackler on his way to a touchdown.
The 49ers offense has been absolutely decimated by injury and now with George Kittle also questionable for Sunday, it’s time to talk about who I think will see the biggest jump in volume; Mr. Brandon Aiyuk.
Last week, in a loss to the Minnesota Vikings, the Niners scored just 17 points and both Deebo/Kittle combined for 18 targets. Those 18 targets equated to 50% of Purdy’s pass attempts with 54% of his completions going to those same 2 guys.
Aiyuk missed all of training camp and the entirety of the pre-season due to contract negotiations with the 49ers. We’ve seen how much players in similar situations have struggled this year due to the lack of practice.
Less practice means fewer reps, fewer reps is what lead’s to the timing issues and a lack of connection between a quarterback and his receivers. It’s also why both Kittle and Samuel have seen 32 combined targets through two weeks; they were present at training camp.
We saw this on full display in Weeks 1 and 2; Aiyuk saw 5 targets but caught just 2 passes for 28 yards, even dropping an easy touchdown. In Week 2 Aiyuk followed it up by catching 4 of his 5 targets for 43 yards in a loss to the Vikings.
Now with no Deebo, no McCaffrey and potentially no Kittle; it’s time for Aiyuk to step up take charge.
Brandon Aiyuk o72.5 Receiving Yards (-111) via BetOnline
Bonus Bet: Brandon Aiyuk 100+ Receiving Yards (+260)
Get 50% up to $1,000 on your NFL picks today at BetOnline
[su_icon icon="icon: star" class="font-weight-bold" background="#fff" color="#FB8500" text_color="#5C6571" size="16" shape_size="4" radius="256" text_size="12" url="/sportsbooks/betonline/" margin="0"] 5/5 Review Rating [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="" margin="0"] $10 Cash Bonus with code "BNEWS" [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="" margin="0"] Sports, Casino, Poker & Racebook [/su_icon]
Brock Purdy to throw 1+ Interception (+102) via BetOnline – Get a $500 WELCOME BONUS
Purdy and the Niners decimated the Rams in his only game against them last year.
With so many offensive pieces missing for Purdy, I get the feeling we could see some tipped balls, and maybe even some timing issues between Purdy and the next guys up. I know that Kittle’s status is still questionable, but even if he plays I like this prop.
Purdy started 16 games last year, threw 31 touchdowns and just 11 interceptions. He failed to record an interception against Los Angeles last year, but this year it’s a very different situation. The Niners enter this game on the road, against a Rams team that is desperate not to go 0-2.
Purdy will be without McCaffrey and without Deebo Samuel this week; two of his biggest weapons on this offense. In a divisional game, on the road, and against a team hungry for their first win of the year. Look for the defense to step up and get us the 1 interception we need.
30% off all Betalytics Packages, Code: BNEWS
Brock Purdy to throw 1+ Interception (+102) via BetOnline
Get 50% up to $1,000 on your NFL picks today at BetOnline
To Recap, NFL Bets for September 22nd, 2024:
In the 49ers vs. Rams game on Sunday, we’re rolling with 2 plays. Brandon Aiyuk o72.5 Receiving Yards (-111), and Brock Purdy to throw 1+ Interception (+102); both via BetOnline.
[su_icon icon="icon: star" class="font-weight-bold" background="#fff" color="#FB8500" text_color="#5C6571" size="16" shape_size="4" radius="256" text_size="12" url="/sportsbooks/betonline/" margin="0"] 5/5 Review Rating [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="" margin="0"] $10 Cash Bonus with code "BNEWS" [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="" margin="0"] Sports, Casino, Poker & Racebook [/su_icon]
Get FREE Picks and Props Weekly
Sign up for
THE WEEKENDER NEWSLETTER
Follow me on ‘X’ @VSaaauce for all my picks and sports takes you didn’t ask for!
Follow Betting News on ‘X’ and Twitch and catch us on stream!
Betting News on TikTok! Follow us for more picks, and news!
In need of a sportsbook? Check out one of our favorites below and sign-up for a bonus!
[su_icon icon="icon: star" class="font-weight-bold" background="#fff" color="#FB8500" text_color="#5C6571" size="16" shape_size="4" radius="256" text_size="12" url="/sportsbooks/betonline/" margin="0"] 5/5 Review Rating [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/betonline/" margin="0"] $10 Cash Bonus with code "BNEWS" [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/betonline/" margin="0"] Sports, Casino, Poker & Racebook [/su_icon]
[su_icon icon="icon: star" class="font-weight-bold" background="#fff" color="#FB8500" text_color="#5C6571" size="16" shape_size="4" radius="256" text_size="12" url="/sportsbooks/sportsbetting/" margin="0"] 4.4/5 Review Rating [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/sportsbetting/" margin="0"] Odds Open Very Early [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/sportsbetting/" margin="0"] Sports, Casino, Poker & Racebook [/su_icon]
[su_icon icon="icon: star" class="font-weight-bold" background="#fff" color="#FB8500" text_color="#5C6571" size="16" shape_size="4" radius="256" text_size="12" url="/sportsbooks/bovada/" margin="0"] 4/5 Review Rating [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/bovada/" margin="0"] Very Fast Payout Times [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/bovada/" margin="0"] Sports, Casino, Poker & Racebook [/su_icon]
[su_icon icon="icon: star" class="font-weight-bold" background="#fff" color="#FB8500" text_color="#5C6571" size="16" shape_size="4" radius="256" text_size="12" url="/sportbet-sportbook-casino-expert-review/" margin="0"] 5/5 Review Rating [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportbet-sportbook-casino-expert-review/" margin="0"] An exclusive VIP program [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportbet-sportbook-casino-expert-review/" margin="0"] Great use of graphics and user-friendly interface [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportbet-sportbook-casino-expert-review/" margin="0"] Multiple currencies supported [/su_icon]
[su_icon icon="icon: star" class="font-weight-bold" background="#fff" color="#FB8500" text_color="#5C6571" size="16" shape_size="4" radius="256" text_size="12" url="/sportsbooks/betwhale/" margin="0"] 4.4/5 Review Rating [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/betwhale/" margin="0"] Best Deposit & Free Play Bonuses [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/betwhale/" margin="0"] Largest Selection of Sports & Games [/su_icon]
[su_icon icon="icon: star" class="font-weight-bold" background="#fff" color="#FB8500" text_color="#5C6571" size="16" shape_size="4" radius="256" text_size="12" url="/sportsbooks/mybookie/" margin="0"] 4.8/5 Review Rating [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/mybookie/" margin="0"] Free $10 Casino Chip with Sign-Up [/su_icon]
[su_icon icon="icon: check-circle" background="#F4F7FC" color="#2FBB9C" text_color="#1F2933" size="16" shape_size="4" radius="256" text_size="14" url="/sportsbooks/mybookie/" margin="0"] Industry-leading Welcome bonus! [/su_icon]
Still Here?
More Betting Stories
- 2024 World Series Prediction & Odds
- 2024 MLB Home Run Leader Predictions & Odds
- 2024 AL/NL MVP Predictions & Picks
- 2024 AL/NL Cy Young Predictions & Picks
[su_box title=”MLB Betting FAQ” style=”default” box_color=”#01337d” title_color=”#ffffff” radius=”3″]
[su_accordion]
[su_spoiler title=”How Do I Safely Bet on Baseball?”]
- Set a betting budget and stick to it.
- Research teams and players thoroughly.
- Choose trustworthy sportsbooks.
- Manage your bankroll wisely.
- Avoid chasing losses.
- Bet responsibly and seek help if needed.
[/su_spoiler]
[su_spoiler title=”What Is the Most Accurate Sportsbook for Betting on the MLB?”]
- BetOnline – 50% up to $1,000
- BetUS – 125% up to $3,125
- SportsBetting – 50% up to $1,000
- Bovada – 50% up to $750
- BetDSI – 100% up to $1,000
- MyBookie – 50% up to $1,000
Check out our full Sportsbook Betting Guide.
[/su_spoiler]
[/su_accordion]
[/su_box]v
You may know me as ‘VSaaauce’. I’ve been a die hard hoops fan my entire life. I’ve been betting on the NBA/NCAAB/NFL/MLB for six years now, each year gaining more and more knowledge about being a profitable handicapper. I’m eager to learn, and eager to pass on everything I’ve gained over the last few years. I started my Twitter page four years ago, and this community makes me so thankful I did. Outside of sports and handicapping, I enjoy traveling, hoopin, a strong espresso and I’m currently studying to obtain my MD. I’m all about the vibes, good vibes only. If that sounds like you, follow me on 'X' @VSaaauce.
This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Betting News makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.
More NFL News on Betting News
Free Betting Picks