Denver Broncos vs. Buffalo Bills Betting: Will we see another high-scoring game at Highmark Stadium?

After rallying to beat the Indianapolis Colts in their first preseason game, the Buffalo Bills will look to improve to 2-0 in preseason play when they face the Denver Broncos on Saturday afternoon.

In their opener last Saturday, the Bills trailed the Colts 24-10 with ten and a half minutes remaining.

But Raheem Blackshear ran for two touchdowns in a little over four minutes to tie it up, and Tyler Bass kicked a game-winning 46-yard field goal as time expired to give the Bills a 27-24 win.

The Bills are at home again this weekend, and they welcome the Broncos, who beat the Dallas Cowboys 17-7 in their preseason opener last Saturday.

Denver Broncos vs. Buffalo Bills Preseason Matchup Information and Betting Odds

Matchup Information

• Matchup: Denver Broncos (1-0 in preseason) vs. Buffalo Bills (1-0 in preseason)
• Venue & Location: Highmark Stadium (Orchard Park, New York)
• Date: Saturday, August 20, 2022
• Game Time: 1:00 p.m. Eastern Time
• Broncos vs. Bills TV Info: NFL Network

Broncos vs. Bills Odds

Game odds are via BetOnline. Odds from other top online sportsbooks may also be mentioned in this article.

Spread

• Denver Broncos +6 (-105)
• Buffalo Bills -6 (-115)

Over/Under

• Over 42 (-110)
• Under 42 (-110)

Moneyline

• Denver Broncos +210
• Buffalo Bills -250

Denver Broncos vs. Buffalo Bills Prediction and Picks

Broncos vs. Bills Prediction: Buffalo 27, Denver 20

Broncos vs. Bills Picks: Buffalo -6 (Best Value: -115 at BetOnline) & Denver/Buffalo over 41.5 (Best Value: -110 at BetMGM)

Last week against the Colts, the Bills scored 27 points and won despite five turnovers.

Even though preseason is about ironing out kinks, position battles, and roster spots, and there’s only so much you can read into it, I do like the Bills to have another productive game on offense, especially if they can keep the turnovers down this week.

In the win over Indianapolis, Matt Barkley (18 of 24, 224 yards, INT) and Case Keenum (11 of 18, 86 yards, 2 INT) combined for over 300 passing yards, and Buffalo threw it early and often.

Denver’s defense did well against Cowboys QBs Ben DiNucci and Cooper Rush, but Buffalo’s duo of Barkley and Keenum, who are locked in a battle for backup behind MVP favorite Josh Allen, should find more success.

The Broncos also had a productive passing performance against the Cowboys, with Josh Johnson (16 of 23, 172 yards, 2 TD) and Brett Rypien (8 of 18, 113 yards) combining for almost 300 yards.

Look for the Bills to cover as they improve to 2-0, and with both teams moving the ball well through the air, a second straight over in Orchard Park is a good bet.

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