NFL Week 12 Predictions, Schedule, Odds, Spread & Over/Under Picks for Thanksgiving Week

The smell of turkey, mashed potatoes, and all the fixings will fill the air as Thanksgiving is just days away. However, feasts aren’t the only thing on the menu this week as Thursday also marks the beginning of the 2023 NFL Week 12 schedule.

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There’ll be plenty to be thankful for this week regarding the incoming football action. After all, all 32 NFL teams will be in action over the coming days, bringing many betting opportunities across all 16 matchups.

Fortunately, your weekly betting primer is here to help you. Let’s dive into my NFL Week 12 predictions and the opening odds and early best bets for each of this week’s games.

All NFL Week 12 odds are courtesy of Bovada at 10:04 a.m. ET on Monday, Nov. 20.

Bye Week Teams: None

NFL Week 12 Predictions & Odds: Thanksgiving Thursday

Packers vs. Lions Odds

• Record: Green Bay Packers (4-6) vs. Detroit Lions (8-2)
• Time: 12:30 p.m. ET
• Location: Ford Field — Detroit, MI
• Spread: Packers +7.5 (-110) | Lions -7.5 (-110)
• Total: OVER 46 (-105) | UNDER 46 (-115)
• Moneyline: Packers +275 | Lions -350

Thanksgiving Thursday kicks off with the second matchup of the year between these NFC North rivals. The Lions got the better of the Packers way back in Week 4, walking out of Lambeau Field with a massive 34-20 victory.

There isn’t a reason to doubt the Lions this time around, either. The Packers are a dismal 0-4 with a minus-2.8 average scoring margin in their last four road games. It’ll only be harder to win in enemy territory due to No. 1 RB Aaron Jones being sidelined with an injury.

Considering how Detroit owns the NFL’s ninth-best average scoring margin at home (plus-9.5), covering the 7.5-point spread shouldn’t be hard for Dan Campbell’s team.

Packers vs. Lions Prediction: DET wins

Packers vs. Lions Best Bet: DET -7.5 (-110)

Commanders vs. Cowboys Odds

• Record: Washington Commanders (4-7) vs. Dallas Cowboys (7-3)
• Time: 4:30 p.m. ET
• Location: AT&T Stadium — Arlington, TX
• Spread: Commanders +11 (-115) | Cowboys -11 (-105)
• Total: OVER 48 (-110) | UNDER 48 (-110)
• Moneyline: Commanders +400 | Cowboys -575

The Commanders and Cowboys are more than familiar with Thanksgiving showdowns. The NFC East rivals have clashed 10 times on the annual holiday, resulting in eight victories for Dallas. However, Washington did emerge with a 41-16 victory the last time they met on Turkey Day back in 2020.

There just isn’t a good reason to believe in a Commanders upset this week. Washington has tasted defeated in seven of its last nine games and is coming off a disappointing 12-point loss to the lowly New York Giants.

Having defeated each of their four previous home foes by 20 or more points, I like the Cowboys’ odds of winning in blowout fashion again.

Commanders vs. Cowboys Prediction: DAL wins

Commanders vs. Cowboys Best Bet: DAL -11 (-105)

49ers vs. Seahawks Odds

• Record: San Francisco 49ers (7-3) vs. Seattle Seahawks (6-4)
• Time: 8:20 p.m. ET
• Location: Lumen Field — Seattle, WA
• Spread: 49ers -7 (-110) | Seahawks +7 (-110)
• Total: OVER 43 (-105) | UNDER 43 (-115)
• Moneyline: 49ers -300 | Seahawks +250

The 49ers finally look like themselves again, heading into the NFL Week 12 slate searching for a third straight win. Meanwhile, the Seahawks need a rebound showing following a 17-16 loss to the rival LA Rams over the weekend.

While the Seahawks have won four straight games at Lumen Field, all good things must come to an end. All but one of those victories came against teams that are currently below .500 and the one that didn’t came against the Browns, who were without Deshaun Watson in Week 7.

Again, I won’t be surprised if the 49ers cover here. Not only are they 4-2 ATS in their last six games against the Seahawks, but they’ve also covered the spread in 10 of their last 11 divisional matchups.

49ers vs. Seahawks Prediction: SF wins

49ers vs. Seahawks Best Bet: SF -7 (-110)

NFL Week 12 Predictions & Odds: Black Friday

Dolphins vs. Jets Odds

• Record: Miami Dolphins (7-3) vs. NY Jets (4-6)
• Time: 3 p.m. ET
• Location: MetLife Stadium (East Rutherford, NJ)
• Spread: Dolphins -7.5 (-110) | Jets +7.5 (-110)
• Total: OVER 41 (-110) | UNDER 41 (-110)
• Moneyline: Dolphins -360 | Jets +280

WR Tyreek Hill’s 146-yard performance played a key role in the Dolphins’ 20-13 win over the Las Vegas Raiders over the weekend. On the flip side, the Jets suffered a third consecutive loss, falling 32-6 to the Buffalo Bills on the road.

Coach Saleh on turning the page quickly in preparation for Miami. pic.twitter.com/r1jSC9x9E2

— New York Jets (@nyjets) November 20, 2023

I won’t overthink this game at all. The Dolphins are legitimate Super Bowl contenders while the Jets are… well, they’re at the point where they just replaced Zach Wilson with Tim Boyle. That’s all you need to know.

Dolphins vs. Jets Prediction: MIA wins

Dolphins vs. Jets Best Bet: MIA -7.5 (-110)

NFL Week 12 Predictions & Odds: Sunday Afternoon

Saints vs. Falcons Odds

• Record: New Orleans Saints (5-5) vs. Atlanta Falcons (4-6)
• Time: 1 p.m. ET
• Location: Mercedes-Benz Stadium (Atlanta, GA)
• Spread: Saints PK (-110) | Falcons PK (-110)
• Total: OVER 41.5 (-110) | UNDER 41.5 (-110)
• Moneyline: Saints -110 | Falcons -110

Sunday’s NFL Week 12 schedule also includes this pick’em situation. The Falcons are back in action following their bye week, hoping that a date with the Saints will help them prevent their losing streak from reaching four games.

Unfortunately for Atlanta, I don’t see New Orleans winning. The Falcons announced that they’re turning back to QB Desmond Ridder, who hasn’t exactly impressed this season, averaging 193.3 passing yards per contest while throwing for six TDs and six INTs.

On top of that, the Saints are 6-1 in their last seven matchups against the Falcons, outscoring their NFC South rivals by an average of 5.7 points. In other words, New Orleans is the correct pick here.

Saints vs. Falcons Prediction: NO wins

Saints vs. Falcons Best Bet: NO ML (-110)

Steelers vs. Bengals Odds

• Record: Pittsburgh Steelers (6-4) vs. Cincinnati Bengals (5-5)
• Time: 1 p.m. ET
• Location: Paycor Stadium (Cincinnati, OH)
• Spread: Steelers -1 (-110) | Bengals +1 (-110)
• Total: OVER 34.5 (-110) | UNDER 34.5 (-110)
• Moneyline: Steelers -115 | Bengals -105

The Bengals’ outlook instantly became grim once QB Joe Burrow suffered a season-ending wrist injury in Week 11. Even though the Steelers have left much to be desired this season, their odds of winning are higher now that they only have to face Jake Browning instead.

I’ll take the Steelers winning in what could wind up being a surprisingly high-scoring affair. After all, the Over is 4-2 in the last six Pittsburgh-Cincinnati matchups, producing an average total of 47.5 points, finishing with more than 34.5 five times.

Furthermore, three of the Steelers’ four road games so far saw more than 34.5 points while each of the Bengals’ last four outings surpassed that number.

Steelers vs. Bengals Prediction: CIN wins

Steelers vs. Bengals Best Bet: o34.5 Total Points (-110)

Panthers vs. Titans Odds

• Record: Carolina Panthers (1-9) vs. Tennessee Titans (3-7)
• Time: 1 p.m. ET
• Location: Nissan Stadium (Nashville, TN)
• Spread: Panthers +4 (-110) | Titans -4 (-110)
• Total: OVER 37 (-110) | UNDER 37 (-110)
• Moneyline: Panthers +165 | Titans -195

The Panthers are struggling to earn their second win of the year, most recently falling 33-10 to the Dallas Cowboys. Things haven’t been going much better for the Titans, who head into the NFL Week 12 slate on a three-game slide.

I don’t like either of these teams this week, hence why I’m siding with the Under as the best bet. For starters, the Under is 11-3 in the Titans’ last 14 games dating back to the 2022 campaign while also being 6-0 in the Panthers’ six latest November tilts.

Additionally, the total has hit the Under four times in the last six meetings between these teams. Considering how they’re also among the NFL’s five lowest-scoring teams this season, there’s no reason to expect fireworks at Nissan Stadium.

Panthers vs. Titans Prediction: TEN wins

Panthers vs. Titans Best Bet: u37 Total Points (-110)

Buccaneers vs. Colts Odds

• Record: Tampa Bay Buccaneers (4-6) vs. Indianapolis Colts (5-5)
• Time: 1 p.m. ET
• Location: Lucas Oil Stadium (Indianapolis, IN)
• Spread: Buccaneers +2.5 (-115) | Colts -2.5 (-105)
• Total: OVER 42.5 (-110) | UNDER 42.5 (-110)
• Moneyline: Buccaneers +115 | Colts -135

Life hasn’t been going well for the Buccaneers, who dropped to 1-5 in their last six games with a 27-14 loss to the San Francisco 49ers. Meanwhile, the Colts are fresh off their bye week and look to extend their winning streak to six games.

Although the Colts aren’t beating the toughest teams lately, they’re in the better spot to win here. The Buccaneers have lost each of their last three road games, allowing 30.0 PPG while being outscored by an average of seven points.

With the Colts’ roster being healthy as the defense has stepped up its play, the home team won’t struggle to win by at least one field goal.

Buccaneers vs. Colts Prediction: IND wins

Buccaneers vs. Colts Best Bet: IND -2.5 (-105)

Patriots vs. Giants Odds

• Record: New England Patriots (2-8) vs. New York Giants (3-8)
• Time: 1 p.m. ET
• Location: MetLife Stadium (East Rutherford, NJ)
• Spread: Patriots -3.5 (-105) | Giants +3.5 (-115)
• Total: OVER 34 (-105) | UNDER 34 (-115)
• Moneyline: Patriots -195 | Giants +165

This NFL Week 12 matchup is a reminder that we aren’t getting Tom Brady vs. Eli Manning anymore. The Patriots exemplify this with their three-game skid while the Giants are coming off a rare win, a 31-19 victory over the Commanders.

Got the dub pic.twitter.com/DWYUBITcut

— New York Giants (@Giants) November 19, 2023

Even though the Patriots are the favorites, they can’t be trusted at all. Not only have they lost three consecutive games, but they’re also 1-3 with a minus-10.4 average road scoring margin — seventh-worst in the NFL. Regardless of who is under center, the results will be the same for New England.

The Giants are easier to trust as underdogs — especially with how well QB Tommy DeVito looked in Week 11, throwing for 246 yards and three TDs without an interception. Back the underdogs at Metlife.

Patriots vs. Giants Prediction: NYG wins

Patriots vs. Giants Best Bet: NYG +3.5 (-115)

Jaguars vs. Texans Odds

• Record: Jacksonville Jaguars (7-3) vs. Houston Texans (6-4)
• Time: 1 p.m. ET
• Location: NRG Stadium (Houston, TX)
• Spread: Jaguars PK (-110) | Giants PK (-110)
• Total: OVER 47 (-110) | UNDER 47 (-110)
• Moneyline: Jaguars -110 | Giants -110

This AFC South collision is yet another pick ‘em situation this week. Despite being the division leaders, the Jaguars could still use some revenge after falling 37-17 to the Texans back in Week 3.

I could see this game going either way. The Jaguars are 6-1 in their last seven games while the Texans are 6-2 in their last eight, mostly due to QB C.J. Stroud’s NFL MVP-level performances. Having said that, Houston has beaten Jacksonville once, and having the home-field advantage this time gives the Texans a good shot of doing it again.

I do like the Over on the 47-point total, though. It’s a number that the Jaguars have surpassed in two of three road games thus far while the Texans’ last three outings saw an average of 56.7 points on the board.

Jaguars vs. Texans Prediction: HOU wins

Jaguars vs. Texans Best Bet: o47 Total Points (-110)

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Now, back to the NFL Week 12 predictions and odds…

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NFL Week 12 Predictions & Odds: Sunday Afternoon

Browns vs. Broncos Odds

• Record: Cleveland Browns (7-3) vs. Denver Broncos (5-5)
• Time: 4:05 p.m. ET
• Location: Empower Field at Mile High (Denver, CO)
• Spread: Browns TBD (TBD) | Broncos TBD (TBD)
• Total: OVER TBD (TBD) | UNDER TBD (TBD)
• Moneyline: Browns TBD | Broncos TBD

Both of these teams head into this tilt on winning streaks. The Browns defeated the Pittsburgh Steelers on Sunday to extend their streak to three games while a 21-20 win over the Minnesota Vikings marked the Broncos’ fourth consecutive victory.

I wouldn’t be surprised if the Broncos pulled off the upset here. The Browns are a worse team without Deshaun Watson, made evident by their beating the Steelers by just three points. Meanwhile, Dever has wins over Buffalo and Kansas City in its last three outings.

Check back later this week when the odds are upset for the best bet, but right now I’m leaning towards a Broncos victory.

Browns vs. Broncos Prediction: DEN wins

Browns vs. Broncos Best Bet: TBD

Rams vs. Cardinals Odds

• Record: LA Rams (4-6) vs. Arizona Cardinals (2-9)
• Time: 4:05 p.m. ET
• Location: State Farm Stadium (Glendale, AZ)
• Spread: Rams -1 (-105) | Cardinals +1 (-115)
• Total: OVER 45.5 (-110) | UNDER 45.5 (-110)
• Moneyline: Rams -115 | Cardinals -105

Even though the Rams are coming off a 17-16 win over the Seahawks, they still lost star WR Cooper Kupp to an ankle injury. On the flip side, the Cardinals returned to the loss column with a 21-16 loss to the Cardinals.

Players injured in Week 11 games who did not return:

QB: Joe Burrow
RB: Aaron Jones
RB: Kenneth Walker
WR: Cooper Kupp
WR: Darius Slayton
TE: Mark Andrews
FLEX: De’Von Achane
IDP: Joey Bosa
BENCH: D’Onta Foreman

Aside from Slayton, a pretty solid Fantasy team. Injuries suck.

— Jamey Eisenberg (@JameyEisenberg) November 20, 2023

Kyler Murray makes Arizona a better team, but there still isn’t much of an incentive for the Cardinals to win here. The Rams still have a somewhat realistic shot of making the playoffs, meaning they’ll be more motivated to pick up the win on the road.

Still, don’t expect a ton of points. The Under is 5-1 in the Rams' last six games on top of being 4-2 in the Cardinals previous six. The NFC West rivals also combined for fewer than 47.5 points in each of their last four meetings, including just 32 when they last met at State Farm Stadium in Sept. 2022.

Chiefs vs. Raiders Odds

• Record: Kansas City Chiefs (7-2) vs. Las Vegas Raiders (5-6)
• Time: 4:25 p.m. ET
• Location: Allegiant Stadium (Las Vegas, NV)
• Spread: Chiefs -9.5 (-110) | Raiders +9.5 (-110)
• Total: OVER 44 (-110) | UNDER 44 (-110)
• Moneyline: Chiefs -450 | Raiders +335

Death, taxes, and the Chiefs beating the Raiders. Since the start of the 2013 NFL season, Kansas City boasts an impressive 17-3 record in its last 20 games against Las Vegas, which includes a five-game heading into this matchup.

Considering how the Chiefs own a plus-12.9 average scoring margin in their last eight road games against the Raiders, I wouldn’t overthink the spread at all. Kansas City will win decisively.

Chiefs vs. Raiders Prediction: KC wins

Chiefs vs. Raiders Best Bet: KC -9.5 (-110)

Bills vs. Eagles Odds

• Record: Buffalo Bills (6-5) vs. Philadelphia Eagles (8-1)
• Time: 4:25 p.m. ET
• Location: Lincoln Financial Field (Philadelphia, PA)
• Spread: Bills +3.5 (-115) | Eagles -3.5 (-105)
• Total: OVER 47.5 (-110) | UNDER 47.5 (-110)
• Moneyline: Bills +150 | Eagles -175

It isn’t a secret that the Bills haven’t been playing well lately, but they hope that a 32-6 win over the Jets gives them momentum ahead of this massive tilt. Meanwhile, the Eagles have yet to play their Week 11 matchup at the time of writing.

I could see this being a back-and-forth affair, resulting in it coming down to a field goal. After all, the Eagles haven’t exactly been as dominant as their record implies. Don’t be surprised if the Bills keep this within a field goal, win or lose.

Bills vs. Eagles Prediction: PHI wins

Bills vs. Eagles Best Bet: BUF +3.5 (-115)

NFL Week 12 Sunday Night Football Predictions

Ravens vs. Chargers Odds

• Record: Baltimore Ravens (8-3) vs. Los Angeles Chargers (4-6)
• Time: 8:20 p.m. ET
• Location: SoFi Stadium (Inglewood, CA)
• Spread: Ravens -4 (-105) | Chargers +4 (-115)
• Total: OVER 46.5 (-110) | UNDER 46.5 (-110)
• Moneyline: Ravens -200 | Chargers +170

Business is booming for the Ravens, who have won five of their last six games and haven’t lost on the road since Week 5. The Chargers, meanwhile, are in danger of losing three straight games due to a defense that has allowed 32.0 PPG in the last two outings.

How dangerous Baltimore’s offense combined with Los Angeles’ defensive struggles spells disaster for the home team. On top of that, the Vikings are the only team that the Chargers have beaten this season that currently sits at an above-.500 record.

With the Ravens poised to challenge for a Super Bowl, expect them to outgun the Chargers.

Ravens vs. Chargers Prediction: BAL wins

Ravens vs. Chargers Best Bet: BAL -4 (-105)

NFL Week 12 Monday Night Football Predictions

Bears vs. Vikings Odds

• Record: Chicago Bears (3-8) vs. Minnesota Vikings (6-5)
• Time: 8:15 p.m. ET
• Location: U.S. Bank Stadium (Minneapolis, MN)
• Spread: Bears +3.5 (-110) | Vikings -3.5 (-110)
• Total: OVER 45.5 (-105) | UNDER 45.5 (-115)
• Moneyline: Bears +165 | Vikings -195

The NFL Week 12 lineup comes to an end with an NFC North showdown on Monday Night Football. The Bears and Vikings previously met for a low-scoring matchup back in Week 6, resulting in a 19-13 victory for Minnesota.

Little about the Bears’ recent play suggests that they’ll upset their rivals — especially after getting outscored 94-56 in three straight road losses this year. The Vikings aren’t perfect, but they have won back-to-back home games by a 6.5-point average.

Having covered the spread in four of their last five meetings with the Bears, I’m confident that the Vikings can hold down the fort one more time.

Bears vs. Vikings Prediction: MIN wins

Bears vs. Vikings Best Bet: MIN -3.5 (-110)

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Super Bowl 58 Odds Before NFL Week 12

Super Bowl LVIII odds courtesy of Bovada as of Monday, Nov. 20.

• Chiefs (+450)
• 49ers (+450)
• Eagles (+550)
• Ravens (+750)
• Cowboys (+950)
• Dolphins (+950)
• Lions (+1000)
• Jaguars (+1600)
• Bills (+2200)
• Browns (+4000)
• Texans (+4500)
• Seahawks (+4500)
• Vikings (+5500)
• Saints (+7000)
• Steelers (+7000)
• Chargers (+8000)
• Bengals (+10000)
• Broncos (+10000)
• Jets (+15000)
• Falcons (+17500)
• Packers (+17500)
• Rams (+20000)
• Buccaneers (+20000)
• Colts (+25000)
• Raiders (+25000)
• Titans (+50000)
• Commanders (+50000)
• Bears (+100000)
• Cardinals (+150000)
• Patriots (+150000)
• Giants (+150000)
• Panthers (+200000)

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Where Can I Bet On NFL Week 12 Games?

Many of the top online sportsbooks offer a wide variety of NFL odds throughout the season.

In addition to being able to bet on Super Bowl spread and over/under odds when the big game arrives, you can make weekly NFL picks on games all season long. Also, you can bet on major awards like NFL MVP, Offensive and Defensive Player of the Year, and more at reputable sports betting sites like the ones below: