NFL Week 12: Lions vs Colts Predictions, Odds & Best Bets

The NFL Week 12 schedule is filled with exciting matchups, including when the Indianapolis Colts (5-6) host the Detroit Lions (9-1) at Lucas Oil Stadium on Sunday. With a plethora of NFL betting opportunities available in this tilt, you’ll want to read through this article for the latest Lions vs. Colts odds and predictions to help you win big.

Without wasting another second, it’s time to get into this Week 12 betting preview!

NFL 2024 Game Record: 7-5-0 (58.3%)

NFL 2024 Best Bet + Prop Bet Record: 11-11-0 (50.0%)

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Lions vs Colts NFL Week 12 Betting (11/24)

Lions vs Colts Game Information

• Matchup: Detroit Lions (9-1, 5-0 Away) vs. Indianapolis Colts (5-6, 3-2 Home)
• Venue & Location: Lucas Oil Stadium (Indianapolis, IN)
• Date: Sunday, Nov. 24, 2024
• Game Time: 1 p.m. ET
• How to Watch Lions vs. Colts: FOX

DET vs IND NFL Week 12 Odds

All NFL odds are courtesy of BetOnline as of Friday, Nov. 22 at 2:32 a.m. ET. Odds from other sportsbooks may also be mentioned in this article.

Lions vs Colts Spread

• Detroit Lions -7.5 (+100)
• Indianapolis Colts +7.5 (-120)

Colts vs Lions Over/Under

• Over 50 Points (-110)
• Under 50 Points (-110)

Lions vs Colts Moneyline

• Detroit Lions (-375)
• Indianapolis Colts (+305)

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Lions vs Colts NFL Week 12 Betting Trends

• Detroit is 8-0 straight up in its last eight games.
• Indianapolis is 3-11 straight up in its last 14 games as the underdog.
• Detroit is 2-4 ATS in its last six games vs. Indianapolis.
• Indianapolis is 9-2 ATS in its last 11 games vs. the NFC North.
• The total hit the Over in six of Detroit’s last seven games vs. the AFC South.
• The total hit the Over in four of Indianapolis’ last five games vs. Detroit.

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Lions vs Colts NFL Week 12 Predictions & Picks (11/24)

The Lions are one of the NFL’s hottest teams and will put their win streak on the line when they visit Lucas Oil Stadium this weekend.

Dan Campbell’s team hasn’t tasted defeat since Week 2, winning each of its last eight games in a row. The Lions’ latest effort saw them pick up a 52-6 victory over the Jacksonville Jaguars last weekend as they amassed a whopping 645 total yards while holding the ball for nearly 40 minutes. It was also the fourth time that Detroit scored 40-plus points during its streak and its second 50-point effort in the last four games.

In other words, the Colts will likely have their work cut out for them come Sunday.

Indianapolis is looking to win consecutive outings for the third time this season following Week 11’s 28-27 win against the New York Jets. It was a game that came down to the wire as Colts quarterback Anthony Richardson scored the game-winning touchdown on a four-yard rush with only 46 seconds remaining in the contest.

Do the Colts have what it takes to pull off an upset at home? 

It’s hard to imagine the Colts keeping pace with the Lions, who average the most points and third-most total yards in the NFL this season. Although Indianapolis scored 28 points last week, that was the exception rather than the rule considering the performance was the team’s second-best output of the year.

It doesn’t help that the Colts have also struggled to score at Lucas Oil Stadium, having been held to 20 or fewer points in their last two home games. Even though the Lions score about eight fewer points on the road than they do at home, their 29.6 PPG clip in away matchups still ranks second-best in the NFL.

The situation worsens given that the Colts are a bottom-10 team against both the pass (26th) and run (28th) this season. The Lions have one of the most diverse attacks in the league and can do damage both through the air and on the ground, meaning things could get ugly quickly if Shane Steichen’s team doesn’t give a 100% effort out of the gate.

That could be easier said than done considering how Indianapolis is only 3-14 SU in its last 17 outings as the underdog. Conversely, Detroit owns an NFL-leading 80.0% win percentage (24-6 SU) as the favorite since the start of the 2021 season.

Will the Lions’ juggernaut-like offense be too much for the Colts to handle? 

Even though the Colts played well in Richardson’s return last week, I’m taking the Lions to win this game. Detroit has solidified itself as one of the Super Bowl favorites throughout the last few months and is capable of beating any team — especially an inconsistent Indianapolis squad. The Colts’ defense just isn’t equipped to handle the Lions’ attack and this game could get ugly if the home team starts off flat-footed.

With this game projected to be a shootout, let’s take the Over on the 50-point total, too. The Over is 4-1 in the last five Lions-Colts meetings as the teams averaged a combined 61.2 PPG while finishing with no fewer than 50 points in any of those contests.

The Over is also 5-2 in the Lions’ last seven games and 2-0 in the Colts’ last two outings, meaning we should see quite a bit of points on the board this weekend.

Lions vs. Colts NFL Week 12 Prediction: DET wins

Best Lions vs. Colts Bet: o50 Total Points (-110)

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Best Lions vs Colts NFL Week 12 Player Prop Bet

Going with David Montgomery o57.5 rushing yards (-117) is the right choice when it comes to Sunday’s Lions vs. Colts player prop pick.

Even though he’s sharing the Lions’ backfield with Jahmyr Gibbs, Montgomery has still been productive. The former Iowa State runner is averaging 59.5 rushing yards per game this season and has already finished with the Over on this prop in five of his 10 appearances so far — including when he amassed 75 rushing yards on 15 attempts against the Jaguars last week. He now has two 70-plus-yard performances in his last three games.

Interestingly enough, he’s also averaging more rushing yards on the road (64.2) than at home (54.8) this season.

Fortunately, for Montgomery, the Colts are allowing 115.1 rushing yards per game to running backs this season and just gave up 78 to Jets RB Breece Hall in Week 11. In other words, expect the veteran RB to find more success in his trip to Indy.

Best Lions vs. Colts Player Prop: David Montgomery o57.5 Rushing Yards (-117)

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