NFL Week 5 Schedule and Odds: AFC Championship Game Rematch in Kansas City Headlines Week 5 Slate

Week 4 of the NFL season is in the books, and we can cast our eyes on what is ahead in Week 5. We will be able to get our NFL betting kicks early on Sunday, as the Falcons meet the Jets in London. Yes, it’s the Falcons and the Jets, but many among us will not pass up the chance to have a side of bets with our Sunday breakfast.

Week 5 gets underway with the Seahawks hosting the Rams on Thursday night. If the first four Thursday night games are any indication, we are in for a close game in Seattle. Carolina’s Week 3 win over Houston is the only one to not be decided by single digits or a last-second field goal. Despite their impressive win in San Francisco on Sunday, the Seahawks are currently a slight underdog against the Rams, who were routed at home by the undefeated Cardinals.

Will Lance Get His First NFL Start Against Undefeated Arizona?

Speaking of MVP favorite Kyler Murray and the 4-0 Cardinals, they have the chance to make another big statement against in Week 5 as they host the 49ers. The 49ers might be happy to hit the road after home losses to the Packers and Seahawks. It’s still early enough for a three-game losing streak to not be a mortal blow, but it would severely limit their margin for error from here.

The big story in San Francisco is whether Jimmy Garoppolo (bruised calf) will start against the Cardinals. If he must sit, Trey Lance will make his first NFL start. Lance took over for Garoppolo in the second half and threw two touchdown passes to Deebo Samuel, including this one. I hear he’s still wide open.

DEEBO IS WIDE OPEN.

Trey Lance finds him for the 76-yard TD! #FTTB

?: #SEAvsSF on FOX
?: NFL app pic.twitter.com/9BRzRkYRNU

— NFL (@NFL) October 3, 2021

Those two NFC West matchups are two of the top Week 5 matchups, but this week’s biggest game is also one of the biggest games of the season. On Sunday night, the Chiefs host the Bills in a rematch of last season’s AFC Championship Game. Will they match up again this season? The Chiefs may be 2-2, but they hold firm as the NFL betting odds favorite to win the AFC, with the Bills next in line.

Are Burrow and the Bengals Ready to Make a Run?

The other standout matchups this week feature 3-1 teams. Joe Burrow and the Cincinnati Bengals have started well, but how seriously should we take them? We’ll get an idea as they host Aaron Rodgers and the Green Bay Packers. In the other 3-1 vs 3-1 matchup, the Los Angeles Chargers host the Cleveland Browns. A win over the Browns, who are third in line in the latest AFC title odds, would enhance Justin Herbert’s MVP odds.

Let’s take a look at the Week 5 schedule and all that is in store for the coming week.

NFL Week 5 Schedule

Thursday, October 7

Los Angeles Rams (3-1) vs Seattle Seahawks (2-2), FOX & NFL Network, 8:20 p.m. ET

Sunday, October 10

New York Jets (1-3) vs Atlanta Falcons (1-3), NFL Network, 9:30 a.m. ET (in London, England)

Green Bay Packers (3-1) vs Cincinnati Bengals (3-1), FOX, 1:00 p.m. ET

Detroit Lions (0-4) vs Minnesota Vikings (1-3), FOX, 1:00 p.m. ET

Denver Broncos (3-1) vs Pittsburgh Steelers (1-3), FOX, 1:00 p.m. ET

Philadelphia Eagles (1-3) vs Carolina Panthers (3-1), FOX, 1:00 p.m. ET

Miami Dolphins (1-3) vs Tampa Bay Buccaneers (3-1), CBS, 1:00 p.m. ET

New England Patriots (1-3) vs Houston Texans (1-3), CBS, 1:00 p.m. ET

New Orleans Saints (2-2) vs Washington Football Team (2-2), CBS, 1:00 p.m. ET

Tennessee Titans (2-2) vs Jacksonville Jaguars (0-4), CBS, 1:00 p.m. ET

Chicago Bears (2-2) vs Las Vegas Raiders (3-1), CBS, 4:05 p.m. ET

Cleveland Browns (3-1) vs Los Angeles Chargers (3-1), CBS, 4:05 p.m. ET

New York Giants (1-3) vs Dallas Cowboys (3-1), FOX, 4:25 p.m. ET

San Francisco 49ers (2-2) vs Arizona Cardinals (2-2), FOX, 4:25 p.m. ET

Buffalo Bills (3-1) vs Kansas City Chiefs (2-2), NBC, 8:20 p.m. ET

Monday, October 11

Indianapolis Colts (1-3) vs Baltimore Ravens (3-1), ESPN, 8:15 p.m. ET

NFL Betting Odds for Week 5

All NFL betting odds listed below are via BetOnline Sportsbook as of Tuesday, October 5, 2021 at 12:30 p.m. ET. To keep up with the latest NFL betting odds from every matchup in Week 5 and all season long, check out our NFL odds page.

Look for our previews of all of the top NFL Week 5 matchups throughout the week. In the meantime, check out our matchup pages for each of matchup on this week’s NFL schedule.

NFL Betting Odds: Los Angeles Rams vs Seattle Seahawks

• Spread: Los Angeles Rams -1.5 (-120), Seattle Seahawks +1.5 (-102)
• Total: OVER 54.5 (-106), UNDER 54.5 (-114)
• Moneyline: Los Angeles Rams -134, Seattle Seahawks +114

Los Angeles Rams vs Seattle Seahawks Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: New York Jets vs Atlanta Falcons

• Spread: New York Jets +3 (-105), Atlanta Falcons -3 (-115)
• Total: OVER 46.5 (-105), UNDER 46.5 (-115)
• Moneyline: New York Jets +144, Atlanta Falcons -174

New York Jets vs Atlanta Falcons Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Green Bay Packers vs Cincinnati Bengals

• Spread: Green Bay Packers -3 (-110), Cincinnati Bengals +3 (-110)
• Total: OVER 50.5 (-110), UNDER 50.5 (-110)
• Moneyline: Green Bay Packers -164, Cincinnati Bengals +138

Green Bay Packers vs Cincinnati Bengals Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Detroit Lions vs Minnesota Vikings

• Spread: Detroit Lions +7.5 (-115), Minnesota Vikings -7.5 (-105)
• Total: OVER 49.5 (-106), UNDER 49.5 (-114)
• Moneyline: Detroit Lions +280, Minnesota Vikings -350

Detroit Lions vs Minnesota Vikings Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Denver Broncos vs Pittsburgh Steelers

• Spread: Denver Broncos +1.5 (-110), Pittsburgh Steelers -1.5 (-110)
• Total: OVER 39.5 (-115), UNDER 39.5 (-105)
• Moneyline: Denver Broncos +102, Pittsburgh Steelers -120

Denver Broncos vs Pittsburgh Steelers Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Philadelphia Eagles vs Carolina Panthers

• Spread: Philadelphia Eagles +3.5 (-106), Carolina Panthers -3.5 (-114)
• Total: OVER 44.5 (-114), UNDER 44.5 (-106)
• Moneyline: Philadelphia Eagles +166, Carolina Panthers -198

Philadelphia Eagles vs Carolina Panthers Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: New England Patriots vs Houston Texans

• Spread: New England Patriots -9 (-110), Houston Texans +9 (-110)
• Total: OVER 39.5 (-114), UNDER 39.5 (-106)
• Moneyline: New England Patriots -405, Houston Texans +320

New England Patriots vs Houston Texans Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Miami Dolphins vs Tampa Bay Buccaneers

• Spread: Miami Dolphins +10.5 (-114), Tampa Bay Buccaneers -10.5 (-106)
• Total: OVER 47.5 (-114), UNDER 47.5 (-106)
• Moneyline: Miami Dolphins +380, Tampa Bay Buccaneers -490

Miami Dolphins vs Tampa Bay Buccaneers Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: New Orleans Saints vs Washington Football Team

• Spread: New Orleans Saints -1.5 (-110), Washington Football Team +1.5 (-110)
• Total: OVER 44.5 (-110), UNDER 44.5 (-110)
• Moneyline: New Orleans Saints -132, Washington Football Team +112

New Orleans Saints vs Washington Football Team Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Tennessee Titans vs Jacksonville Jaguars

• Spread: Tennessee Titans -4 (-110), Jacksonville Jaguars +4 (-110)
• Total: OVER 48.5 (-106), UNDER 48.5 (-114)
• Moneyline: Tennessee Titans -200, Jacksonville Jaguars +168

Tennessee Titans vs Jacksonville Jaguars Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Chicago Bears vs Las Vegas Raiders

• Spread: Chicago Bears +5.5 (-110), Las Vegas Raiders -5.5 (-110)
• Total: OVER 45 (-110), UNDER 45 (-110)
• Moneyline: Chicago Bears +198, Las Vegas Raiders -240

Chicago Bears vs Las Vegas Raiders Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Cleveland Browns vs Los Angeles Chargers

• Spread: Cleveland Browns +1 (-110), Los Angeles Chargers -1 (-110)
• Total: OVER 48.5 (-110), UNDER 48.5 (-110)
• Moneyline: Cleveland Browns -102, Los Angeles Chargers -116

Cleveland Browns vs Los Angeles Chargers Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: New York Giants vs Dallas Cowboys

• Spread: New York Giants +7 (-110), Dallas Cowboys -7 (-110)
• Total: OVER 52.5 (-110), UNDER 52.5 (-110)
• Moneyline: New York Giants +250, Dallas Cowboys -310

New York Giants vs Dallas Cowboys Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: San Francisco 49ers vs Arizona Cardinals

• Spread: San Francisco 49ers +5.5 (-110), Arizona Cardinals -5.5 (-110)
• Total: OVER 50.5 (-104), UNDER 50.5 (-118)
• Moneyline: San Francisco 49ers +205, Arizona Cardinals -250

San Francisco 49ers vs Arizona Cardinals Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Buffalo Bills vs Kansas City Chiefs

• Spread: Buffalo Bills +3 (-115), Kansas City Chiefs -3 (-105)
• Total: OVER 56.5 (-110), UNDER 56.5 (-110)
• Moneyline: Buffalo Bills +126, Kansas City Chiefs -148

Buffalo Bills vs Kansas City Chiefs Matchup: NFL Betting Picks, Odds, Stats and More

NFL Betting Odds: Indianapolis Colts vs Baltimore Ravens

• Spread: Indianapolis Colts +7 (-110), Baltimore Ravens -7 (-110)
• Total: OVER 46.5 (-105), UNDER 46.5 (-115)
• Moneyline: Indianapolis Colts +265, Baltimore Ravens -330